Be aware of the following notes from pgs. 179-180 of the manual:
Attention - Changing the final drive ratio is only allowed for circuit (racetrack) use of the motorcycle, not on public roads.
Attention - In the event of front sprocket and/or rear sprocket replacement, after performing the “TyreCalibration” procedure, it is necessary to go to an authorised Ducati dealer who will perform a “drive adaptive system reset” with the diagnosis instrument. This allows you to avoid false plausibility diagnoses related to the final drive ratio modification.
Attention - Changing the final drive ratio immediately makes the warranty null and void and the motorcycle can not be used on public roads as it no longer corresponds to the type-approved version.
Additionally, they toss in a lot of qualifying statements about requiring "OE tyres" for the proper function of rider aids like DTC, DPL, ABS, etc.